A white-knuckle ride of open COVID drug discovery

Frank von Delft, Mark Calmiano, John Chodera, Ed Griffen, Alpha Lee, Nir London, Tatiana Matviuk, Ben Perry, Matt Robinson, and Annette von Delft.
Nature 594:330, 2021.
[DOI] [PDF]

The COVID Moonshot is an open science effort to discover a direct-acting SARS-CoV-2 oral antiviral. Here, we share lessons from this effort, including the missed opportunity to develop a phase 2 ready drug more than a decade ago that could have halted the COVID-19 pandemic in its tracks.

The Social Network (of protein conformations)

John D. Chodera and Vijay S. Pande.
Proc. Natl. Acad. Sci. USA 108:12969, 2011. [DOI] [PDF]

Commentary: A new methodology for mapping protein conformational spaces is reminiscent of how we use two-dimensional maps to navigate a three-dimensional world.